Line-field confocal optical coherence tomography

Jonas Ogien (1) , Olivier Levecq (1) , Hicham Azimani (1) , Arthur Davis (1) , Weikai Xue , David Siret (1) , Jean-Luc Perrot (2) , Arnaud Dubois (1)

1 Laboratoire Charles Fabry / Biophotonique
2 Valorial - Valorisation Recherche et Innovations Alimentaire

A time-domain optical coherence tomography technique is presented for ultrahigh-resolution B-scan imaging in real-time. The technique is based on a two-beam interference microscope with line illumination and line detection, using a supercontinuum laser and a line-scan camera. Multiple (2048) A-scans are acquired in parallel by scanning the sample depth while adjusting the focus. A quasi isotropic spatial resolution of 1.3 µm × 1.1 µm (lateral × axial) is achieved. In vivo cellular level resolution imaging of normal and cancerous human skin is demonstrated at 10 frame/s with a penetration depth of ∼ 500 µm.

Domains: Physics [physics]; Physics [physics]; Optics [physics.optics]

Jonas Ogien, Olivier Levecq, Hicham Azimani, Arthur Davis, Weikai Xue, et al.. Line-field confocal optical coherence tomography. SPIE's International Symposium on Biomedical Optics (BiOS), Feb 2019, San-Francisco, United States. ⟨10.1117/12.2507244⟩. ⟨hal-02197158⟩