Line-field confocal time-domain optical coherence tomography with dynamic focusing

Arnaud Dubois (1) , Olivier Levecq (1) , Hicham Azimani (1) , Arthur Davis (1) , Jonas Ogien (1) , David Siret (1) , Anaïs Barut

1 Laboratoire Charles Fabry / Biophotonique

A time-domain optical coherence tomography technique is introduced for high-resolution B-scan imaging in real-time. The technique is based on a two-beam interference microscope with line illumination and line detection using a broadband spatially coherent light source and a line-scan camera. Multiple (2048) A-scans are acquired in parallel by scanning the sample depth while adjusting the focus. Quasi-isotropic spatial resolution of 1.3 µm × 1.1 µm (lateral × axial) is achieved. In vivo cellular-level resolution imaging of human skin is demonstrated at 10 frames per second with a penetration depth of ∼500 µm.

Domains: Physics [physics]; Physics [physics]; Optics [physics.optics]

Arnaud Dubois, Olivier Levecq, Hicham Azimani, Arthur Davis, Jonas Ogien, et al.. Line-field confocal time-domain optical coherence tomography with dynamic focusing. Optics Express, 2018, 26 (26), pp.33534. ⟨10.1364/oe.26.033534⟩. ⟨hal-01950735⟩