Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity.

Olivier Le Bacquer (1) , Kristell Combe (1) , Christophe Montaurier (1) , Jérôme Salles (1) , Christophe Giraudet (1) , Véronique Patrac (1) , Carla Domingues-Costa Faria (1) , Christelle Guillet (1) , Katie Louche (2, 3, 4) , Yves Boirie (1, 5) , Nahum Sonenberg (6) , Cédric Moro (2, 3, 4) , Stephane Walrand (1)

1 UNH - Unité de Nutrition Humaine
2 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
3 INSERM - Institut National de la Santé et de la Recherche Médicale
4 UT3 - Université Toulouse III - Paul Sabatier
5 Service Nutrition Clinique
6 Department of Biochemistry

Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity.

Mots clés: ATGL; lipid accumulation; lipotoxicity; mTOR; protein homeostasis; obesity; protein; voluntary muscle

Mots clés: obésité; insulino- résistance; accumulation de lipides; protéine; muscle squelettique

Domaines: Alimentation et Nutrition

Olivier Le Bacquer, Kristell Combe, Christophe Montaurier, Jérôme Salles, Christophe Giraudet, et al.. Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity.. Molecular Nutrition and Food Research, 2017, 61 (9), ⟨10.1002/mnfr.201700128⟩. ⟨hal-01594848⟩