Mutating the cholesterol binding site on amyloid precursor protein alters the processing and production of Aβ-amyloid peptides

L. Hanbouch (1) , C. Marquer (1) , L. Boussicault (1) , B. Schaack (2) , Karen Perronet (3) , Julien Moreau (3) , N. Gilles (4) , C. Louis (5) , M.J. Millan (5) , M.C. Potier (1)

1 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
2 IBS - UMR 5075 - Institut de biologie structurale
3 Laboratoire Charles Fabry / Biophotonique
4 Centre de recherche du CEA/DSV/iBiTec-S/SIMOPRO
5 Institut de Recherches Servier

Domaines: Sciences du Vivant [q-bio]

L. Hanbouch, C. Marquer, L. Boussicault, B. Schaack, Karen Perronet, et al.. Mutating the cholesterol binding site on amyloid precursor protein alters the processing and production of Aβ-amyloid peptides. European Neuropsychopharmacology, 2018, 28, pp.S6-S7. ⟨10.1016/j.euroneuro.2017.12.023⟩. ⟨hal-04400363⟩