Western diet feeding since adolescence impairs functional hyperemia probed by functional ultrasound imaging at adulthood and middle age: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio in the diet - Institut d'Optique Graduate School
Preprints, Working Papers, ... Year : 2023

Western diet feeding since adolescence impairs functional hyperemia probed by functional ultrasound imaging at adulthood and middle age: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio in the diet

Abstract

Abstract Obesity is a devastating worldwide metabolic disease, with the highest prevalence in children and adolescence. Obesity impacts neuronal function but the fate of functional hyperemia, a vital mechanism making possible cerebral blood supply to active brain areas, is unknown in organisms fed a high caloric Western Diet (WD) since adolescence. We mapped changes in cerebral blood volume (CBV) in the somatosensory cortex in response to whiskers stimulation in adolescent, adult and middle-aged mice fed a WD since adolescence. To this aim, we used non-invasive and high-resolution functional ultrasound imaging (fUS). Functional hyperemia is compromised as early as 3 weeks of WD and remains impaired thereafter. Starting WD in adult mice does not trigger the profound impairment in sensory-evoked CBV observed in young mice, suggesting a cerebrovascular vulnerability to WD during adolescence. A balanced ω-6:ω-3 polyunsaturated fatty acids ratio in WD achieved by docosahexaenoic acid supplementation is efficient to restore glucose homeostasis and functional hyperemia in adults.

Dates and versions

hal-04400349 , version 1 (17-01-2024)

Identifiers

Cite

Haleh Soleimanzad, Clémentine Morisset, Mireia Montaner, Frédéric Pain, Christophe Magnan, et al.. Western diet feeding since adolescence impairs functional hyperemia probed by functional ultrasound imaging at adulthood and middle age: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio in the diet. 2024. ⟨hal-04400349⟩
23 View
0 Download

Altmetric

Share

More