Line-field confocal optical coherence tomography for three-dimensional skin imaging

Jonas Ogien (1) , Anthony Daures (1) , Maxime Cazalas (1) , Jean-Luc Perrot (2) , Arnaud Dubois (3)

1 DAMAE - DAMAE Medical
2 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
3 Laboratoire Charles Fabry / Biophotonique

This paper reports on the latest advances in line-field confocal optical coherence tomography (LC-OCT), a recently invented imaging technology that now allows the generation of either horizontal (x  y) section images at an adjustable depth or vertical (x  z) section images at an adjustable lateral position, as well as threedimensional images. For both two-dimensional imaging modes, images are acquired in real-time, with real-time control of the depth and lateral positions. Three-dimensional (x  y  z) images are acquired from a stack of horizontal section images. The device is in the form of a portable probe. The handle of the probe has a button and a scroll wheel allowing the user to control the imaging modes. Using a supercontinuum laser as a broadband light source and a high numerical microscope objective, an isotropic spatial resolution of ~1 mm is achieved. The field of view of the three-dimensional images is 1.2 mm  0.5 mm  0.5 mm (x  y  z). Images of skin tissues are presented to demonstrate the potential of the technology in dermatology.

Keywords: optical coherence tomography (OCT) microscopy three-dimensional imaging dermatology; optical coherence tomography (OCT); microscopy; three-dimensional imaging; dermatology; optical coherence tomography (OCT) microscopy three-dimensional imaging dermatology

Domains: Physics [physics]

Jonas Ogien, Anthony Daures, Maxime Cazalas, Jean-Luc Perrot, Arnaud Dubois. Line-field confocal optical coherence tomography for three-dimensional skin imaging. Frontiers of Optoelectronics, 2020, 13, pp.381 - 392. ⟨10.1007/s12200-020-1096-x⟩. ⟨hal-04282339⟩