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Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo

Abstract : Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced technique for ultrahigh-resolution vertical section (B-scan) imaging of human skin in vivo. This work presents a new implementation of the LC-OCT technique to obtain horizontal section images (C-scans) in addition to B-scans. C-scan imaging is achieved with this dual-mode LC-OCT system using a mirror galvanometer for lateral scanning along with a piezoelectric chip for modulation of the interferometric signal. A quasi-identical spatial resolution of 1 µm is measured for both B-scans and C-scans. The images are acquired in both modes at a rate of 10 frames per second. The horizontal field of view of the C-scans is 1.2 * 0.5 mm2 , identical to the vertical field of view of the B-scans. The user can switch between the two modes by clicking a button. In vivo cellular-resolution imaging of human skin is demonstrated in both B-scan and C-scan modes, with the possibility to navigate within the skin tissues in real time.
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Submitted on : Wednesday, February 19, 2020 - 10:18:24 AM
Last modification on : Wednesday, September 16, 2020 - 5:48:34 PM
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Biomed. Opt. Express 2020 (Dua...
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Jonas Ogien, Olivier Levecq, Hicham Azimani, Arnaud Dubois. Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo. Biomedical optics express, Optical Society - SOA Publishing, 2019, ⟨10.1364/BOE.385303⟩. ⟨hal-02484205⟩

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