Skin lesion imaging with line-field confocal optical coherence tomography

Maxime Cazalas , Olivier Levecq (1) , Hicham Azimani (1) , David Siret (1) , Anaïs Barut , Mariano Suppa , Véronique del Marmol , Josep Malvehy (2) , Élisa Cinotti (3) , Pietro Rubegni , Jean-Luc Perrot , Arnaud Dubois

1 Laboratoire Charles Fabry / Biophotonique
2 Hospital Clínic de Barcelona
3 SNA - EPIS - Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé

An original OCT technique called line-field confocal OCT (LC-OCT) is presented. Combining the principles of time-domain OCT and confocal microscopy with line illumination and detection, LC-OCT acquires multiple A-scans in parallel with dynamic focusing. With a quasi isotropic resolution of 1 µm, the LC-OCT images reveal a comprehensive structural mapping of skin, in vivo, at the cellular level down to a depth of 500 µm. LC-OCT images of various skin lesions, including carcinomas and melanomas, are found to strongly correlate with histopathological images. LC-OCT could significantly improve clinical diagnostic accuracy, while reducing the number of biopsies of benign lesions.

Domains: Optics [physics.optics]

Maxime Cazalas, Olivier Levecq, Hicham Azimani, David Siret, Anaïs Barut, et al.. Skin lesion imaging with line-field confocal optical coherence tomography. SPIE's International Symposium on Biomedical Optics (BiOS), Feb 2019, San-Francisco, United States. ⟨10.1117/12.2508484⟩. ⟨hal-02197166⟩