Surface plasmon resonance imaging instrumentation and data handling for biochips: review and perspectives

Abstract : Sensors based on surface plasmon resonance have the potential to provide information on the binding of biological molecules on adequate substrates over typically thousand channels in parallel, without the need for any marker and in real time compared to the scale of biochemical reactions. The need to optimize selectivity and sensitivity has triggered continued research efforts. We review those related with optics and image processing, at the same time identifying some aspects that deserve further investigation before the potential of the technique is fully utilized.