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Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2009

Bursting of sensitive polymersomes induced by curling

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Elyes Mabrouk
  • Function : Author
  • PersonId : 941115
Damien Cuvelier
  • Function : Author
  • PersonId : 941107
Françoise Brochard-Wyart
Pierre Nassoy
  • Function : Author
  • PersonId : 956882
Min-Hui Li
  • Function : Author
  • PersonId : 941116

Abstract

Polymersomes, which are stable and robust vesicles made of block copolymer amphiphiles, are good candidates for drug carriers or micro/nanoreactors. Polymer chemistry enables almost unlimited molecular design of responsive polymersomes whose degradation upon environmental changes has been used for the slow release of active species. Here, we propose a strategy to remotely trigger instantaneous polymersome bursting. We have designed asymmetric polymer vesicles, in which only one leaflet is composed of responsive polymers. In particular, this approach has been successfully achieved by using a UV-sensitive liquid-crystalline copolymer. We study experimentally and theoretically this bursting mechanism and show that it results from a spontaneous curvature of the membrane induced by the remote stimulus. The versatility of this mechanism should broaden the range of applications of polymersomes in fields such as drug delivery, cosmetics and material chemistry.
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Dates and versions

hal-01002414 , version 1 (06-06-2014)

Identifiers

  • HAL Id : hal-01002414 , version 1

Cite

Elyes Mabrouk, Damien Cuvelier, Françoise Brochard-Wyart, Pierre Nassoy, Min-Hui Li. Bursting of sensitive polymersomes induced by curling. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (18), pp.7294-7298. ⟨hal-01002414⟩
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