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Conference Papers Year : 2012

Microscopie à fluorescence et tomographie par cohérence optique en plein champ

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Abstract

Full-field optical coherence microscopy (FF-OCM) and optically-sectioned fluorescence microscopy are implemented simultaneously in a dual modality imaging system. Both modalities use a broad field illumination and acquire the entire field of view without raster scanning. Optical sectioning is achieved owing to the coherence gating property of light for FF-OCM, and structured illumination for fluorescence microscopy. The dual modality system provides complementary images in the context of biological tissue screening. FF-OCM shows the tissue micro-architecture, while fluorescence microscopy highlights specific tissue features with cellular-level resolution by using targeting contrast agents. Complementary tissue morphology and biochemical features could potentially improve the understanding of cellular functions and disease diagnosis.
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Dates and versions

hal-00702695 , version 1 (31-05-2012)

Identifiers

  • HAL Id : hal-00702695 , version 1

Cite

Houssine Makhlouf, Karen Perronet, Guillaume Dupuis, Sandrine Leveque-Fort, Arnaud Dubois. Microscopie à fluorescence et tomographie par cohérence optique en plein champ. OptDiag 2012 Diagnostic et Imagerie Optique en Médecine et Biologie Biophotonique, May 2012, Paris, France. pp.000. ⟨hal-00702695⟩
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