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Microscopie à fluorescence et tomographie par cohérence optique en plein champ

Abstract : Full-field optical coherence microscopy (FF-OCM) and optically-sectioned fluorescence microscopy are implemented simultaneously in a dual modality imaging system. Both modalities use a broad field illumination and acquire the entire field of view without raster scanning. Optical sectioning is achieved owing to the coherence gating property of light for FF-OCM, and structured illumination for fluorescence microscopy. The dual modality system provides complementary images in the context of biological tissue screening. FF-OCM shows the tissue micro-architecture, while fluorescence microscopy highlights specific tissue features with cellular-level resolution by using targeting contrast agents. Complementary tissue morphology and biochemical features could potentially improve the understanding of cellular functions and disease diagnosis.
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https://hal-iogs.archives-ouvertes.fr/hal-00702695
Contributor : Karen Perronet <>
Submitted on : Thursday, May 31, 2012 - 10:22:02 AM
Last modification on : Wednesday, September 16, 2020 - 5:38:30 PM
Long-term archiving on: : Saturday, September 1, 2012 - 2:22:29 AM

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  • HAL Id : hal-00702695, version 1

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Houssine Makhlouf, Karen Perronet, Guillaume Dupuis, Sandrine Leveque-Fort, Arnaud Dubois. Microscopie à fluorescence et tomographie par cohérence optique en plein champ. OptDiag 2012 Diagnostic et Imagerie Optique en Médecine et Biologie Biophotonique, May 2012, Paris, France. pp.000. ⟨hal-00702695⟩

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