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Quantitative-analysis of computed tomography in COVID-19 and non COVID-19 ARDS patients: A case-control study

Abstract : Highlights• Lung weight is significantly increased in all COVID+ ARDS patients.• Lung potential for recruitment of COVID+ ARDS patients is lower than COVID− ARDS.• A substantial proportion of COVID+ patients exhibit large amount of tidal hyperinflation.PurposeThe aim of this study was to assess whether the computed tomography (CT) features of COVID-19 (COVID+) ARDS differ from those of non-COVID-19 (COVID−) ARDS patients.Materials and methodsThe study is a single-center prospective observational study performed on adults with ARDS onset ≤72 h and a PaO2/FiO2 ≤ 200 mmHg. CT scans were acquired at PEEP set using a PEEP-FiO2 table with VT adjusted to 6 ml/kg predicted body weight.Results22 patients were included, of whom 13 presented with COVID-19 ARDS. Lung weight was significantly higher in COVID− patients, but all COVID+ patients presented supranormal lung weight values. Noninflated lung tissue was significantly higher in COVID− patients (36 ± 14% vs. 26 ± 15% of total lung weight at end-expiration, p < 0.01). Tidal recruitment was significantly higher in COVID− patients (20 ± 12 vs. 9 ± 11% of VT, p < 0.05). Lung density histograms of 5 COVID+ patients with high elastance (type H) were similar to those of COVID− patients, while those of the 8 COVID+ patients with normal elastance (type L) displayed higher aerated lung fraction.
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https://hal.archives-ouvertes.fr/hal-03149581
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Submitted on : Thursday, August 25, 2022 - 4:38:07 PM
Last modification on : Tuesday, October 18, 2022 - 4:31:07 AM
Long-term archiving on: : Saturday, November 26, 2022 - 9:13:26 PM

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Louis Chauvelot, Laurent Bitker, François Dhelft, Mehdi Mezidi, Maciej Orkisz, et al.. Quantitative-analysis of computed tomography in COVID-19 and non COVID-19 ARDS patients: A case-control study. Journal of Critical Care, 2020, 60, pp.169-176. ⟨10.1016/j.jcrc.2020.08.006⟩. ⟨hal-03149581⟩

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