Ultra high dose rate Synchrotron Microbeam Radiation Therapy. Preclinical evidence in view of a clinical transfer

Laura Eling (1) , Audrey Bouchet (1) , Christian Nemoz (2) , Valentin Djonov (3) , Jacques Balosso (4) , Jean A. Laissue (5) , Elke Bräuer-Krisch (2) , Jean-François Adam (1) , Raphaël Serduc (1)

1 STROBE - Synchrotron Radiation for Biomedicine = Rayonnement SynchroTROn pour la Recherche BiomédicalE
2 ID17 - Biomedical Beamline
3 Institute of Anatomy
4 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
5 Oncology - Pathology - Anatomy

Highlights •MRT is a form of synchrotron generated X-ray radiosurgery dedicated to brain tumours. •Normal tissue tolerates high X-ray dose thanks through lattice of microbeams. •MRT operates at very high dose rate (kGy·s−1) and triggers FLASH effect in vivo.AbstractThis paper reviews the current state of the art of an emerging form of radiosurgery dedicated to brain tumour treatment and which operates at very high dose rate (kGy·s−1). Microbeam Radiation Therapy uses synchrotron-generated X-rays which triggered normal tissue sparing partially mediated by FLASH effect.

Mots clés: Synchrotron Microbeam Radiation Therapy; High dose rate; Normal tissue sparing; Brain tumours responses

Domaines: Physique Médicale [physics.med-ph]; Cancer

Laura Eling, Audrey Bouchet, Christian Nemoz, Valentin Djonov, Jacques Balosso, et al.. Ultra high dose rate Synchrotron Microbeam Radiation Therapy. Preclinical evidence in view of a clinical transfer. Radiotherapy & Oncology, 2019, 139, pp.56-61. ⟨10.1016/j.radonc.2019.06.030⟩. ⟨hal-02510707⟩