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A high-stringency blueprint of the human proteome

S Adhikari 1 Edouard C Nice 2, 1 E Deutsch 3 Lydie Lane 4 Gilbert S Omenn 5 Stephen R Pennington 6 Young-Ki Paik 7 Christopher M Overall 8 Fernando J Corrales 9 Ileana M Cristea 10 Jennifer E van Eyk 11 Mathias Uhlén 12 Cecilia Lindskog 13 Daniel W Chan 14 Amos Bairoch 4 James C Waddington 6 Joshua L Justice 10 Joshua Labaer 15 Henry Rodriguez 16, 17 Fuchu He Markus Kostrzewa 18 Peipei Ping 19 Rebekah L Gundry 20 Peter Stewart Sanjeeva Srivastava 21 Sudhir Srivastava 17, 16 Fabio C S Nogueira 22 Gilberto B Domont Yves Vandenbrouck 23 Maggie P Y Lam 24 Sara Wennersten 24 Juan Antonio Vizcaíno 25 Marc Wilkins 26 Jochen M Schwenk 12 Emma Lundberg 12 Nuno Bandeira 27, 28 György Marko-Varga 29 Susan T Weintraub 30 Charles Pineau 31 Ulrike Kusebauch 3 Robert L Moritz 3 Seong Beom Ahn 1 Magnus Palmblad 32 Michael P Snyder 33 Ruedi Aebersold 34, 3 Mark S Baker 1, 35, 33
Abstract : The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
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S Adhikari, Edouard C Nice, E Deutsch, Lydie Lane, Gilbert S Omenn, et al.. A high-stringency blueprint of the human proteome. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.5301. ⟨10.1038/s41467-020-19045-9⟩. ⟨hal-03004830⟩



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