Skip to Main content Skip to Navigation
Journal articles

A high-stringency blueprint of the human proteome

S Adhikari 1 Edouard C Nice 2, 1 E Deutsch 3 Lydie Lane 4 Gilbert S Omenn 5 Stephen R Pennington 6 Young-Ki Paik 7 Christopher M Overall 8 Fernando J Corrales 9 Ileana M Cristea 10 Jennifer E van Eyk 11 Mathias Uhlén 12 Cecilia Lindskog 13 Daniel W Chan 14 Amos Bairoch 4 James C Waddington 6 Joshua L Justice 10 Joshua Labaer 15 Henry Rodriguez 16, 17 Fuchu He Markus Kostrzewa 18 Peipei Ping 19 Rebekah L Gundry 20 Peter Stewart Sanjeeva Srivastava 21 Sudhir Srivastava 17, 16 Fabio C S Nogueira 22 Gilberto B Domont Yves Vandenbrouck 23 Maggie P Y Lam 24 Sara Wennersten 24 Juan Antonio Vizcaíno 25 Marc Wilkins 26 Jochen M Schwenk 12 Emma Lundberg 12 Nuno Bandeira 27, 28 György Marko-Varga 29 Susan T Weintraub 30 Charles Pineau 31 Ulrike Kusebauch 3 Robert L Moritz 3 Seong Beom Ahn 1 Magnus Palmblad 32 Michael P Snyder 33 Ruedi Aebersold 34, 3 Mark S Baker 1, 35, 33
1 Macquarie University
2 Monash University [Melbourne]
3 ISB - Institute for Systems Biology [Seattle]
4 CMU - Centre médical universitaire de Genève
5 University of Michigan [Ann Arbor]
6 UCD - University College Dublin [Dublin]
7 Yonsei University
8 UBC - University of British Columbia
9 CNB-CSIC - Centro Nacional de Biotecnología [Madrid]
10 Princeton University
11 Cedars-Sinai Medical Center
12 KTH - Royal Institute of Technology [Stockholm]
13 Uppsala University
14 Johns Hopkins University School of Medicine [Baltimore]
15 ASU - Arizona State University [Tempe]
16 NIH - National Institutes of Health [Bethesda]
17 NCI-NIH - National Cancer Institute [Bethesda]
18 Bruker Daltonik GmbH
19 David Geffen School of Medicine [Los Angeles]
20 University of Nebraska Medical Center
21 IIT Bombay - Indian Institute of Technology Bombay
22 PUC-Rio - Pontifícia Universidade Católica do Rio de Janeiro
23 BGE - UMR S1038 - Laboratoire de Biologie à Grande Échelle
24 University of Colorado Anschutz [Aurora]
25 EMBL-EBI - European Bioinformatics Institute [Hinxton]
26 UNSW - University of New South Wales [Sydney]
27 UC San Diego - University of California [San Diego]
28 CSE-UCSD - Department of Computer Science and Engineering [San Diego]
29 Lund University [Lund]
30 University of Texas Health Science Center
31 Irset - Institut de recherche en santé, environnement et travail
32 Leiden University Medical Center (LUMC)
33 Stanford University School of Medicine [CA, USA]
34 UZH - Universität Zürich [Zürich] = University of Zurich
35 Stanford School of Medicine [Stanford]
Abstract : The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
Document type :
Journal articles
Complete list of metadata
https://hal.archives-ouvertes.fr/hal-03004830
Contributor : Admin Hal Ur1 Connect in order to contact the contributor
Submitted on : Friday, May 28, 2021 - 10:58:01 AM
Last modification on : Wednesday, March 30, 2022 - 2:40:44 PM

File

Vignette du document
s41467-020-19045-9.pdf
Publisher files allowed on an open archive

Identifiers

Collections

INSERM | UR1-UFR-SVE | IRSET-7 | UNIV-RENNES | IRIG | CEA-GRE | UR1-BIO-SA | CEA | UNIV-RENNES1 | UGA | UNIV-ANGERS | IRSET | IRTSV-BGE | CEA-DRF

Citation

S Adhikari, Edouard C Nice, E Deutsch, Lydie Lane, Gilbert S Omenn, et al.. A high-stringency blueprint of the human proteome. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.5301. ⟨10.1038/s41467-020-19045-9⟩. ⟨hal-03004830⟩

Export

BibTeX TEI DC DCterms EndNote Datacite

Share

Metrics

Record views

55

Files downloads

26