Biomechanical characterization of ex vivo human brain using ultrasound shear wave spectroscopy

Résumé : The characterization of brain tissue is crucial to better understand neurological disorders. Mechanical characterization is an emerging tool in that field. The purpose of this work was to validate a transient ultrasound technique aimed at measuring dispersion of mechanical parameters of the brain tissue. The first part of this work was dedicated to the validation of that technique by comparing it with two proven rheology methods: a rotating plate rheometer, and a viscoelastic spectroscopy apparatus. Experiments were done on tissue mimicking gels. Results were compared on storage and loss modulus in the 20-100Hz band. Our method was validated for the measurement of storage modulus dispersion, with some reserves on the measurement of loss modulus. The second part of this work was the measurement of the mechanical characteristics of ex vivo human white matter. We were able to measure the dispersion of the storage and loss modulus in the 20-100Hz band, fitting the data with a custom power law model.
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Soumis le : jeudi 30 novembre 2017 - 16:35:01
Dernière modification le : vendredi 18 mai 2018 - 01:11:23

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Emmanuel Nicolas, Samuel Calle, Stéphane Nicolle, David Mitton, Jean-Pierre Remenieras. Biomechanical characterization of ex vivo human brain using ultrasound shear wave spectroscopy. Ultrasonics, Elsevier, 2018, 84, pp.119-125. 〈10.1016/j.ultras.2017.10.009〉. 〈hal-01652774〉

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