Skip to Main content Skip to Navigation
Theses

Architectures moléculaires complexes pour la reconnaissance de bio(macro)molécules d'intérêt thérapeutique

Abstract : The recognition of biomolecules in complex biological media is a challenge associated with various therapeutic applications. The chemist can address this issue following two approaches: either he designs him-self and synthesises its molecules or he selects a commercially available or natural molecule and directly uses it for its properties. Following the last strategy, dendrigraft of lysine (DGL) efficiently neutralised all classes of the anticoagulant heparin, with a superior effect compared to protamine, the only FDA-approved drug in case of heparin overdosage. A study by molecular dynamic revealed the mechanism of binding between heparins and DGL and protamine respectively. At the opposite of this approach, we used dynamic combinatorial chemistry in order to obtain disulfide bridged cyclophanes from the self-assembly of various 1,4-bisthiophenols by oxidation of thiols into disulfide bonds. By a combination of theoretical (DFT and molecular dynamic) and experimental studies, we investigated the driving forces and the influences of fundamental concepts such as solvation and steric effects for the self-assembly of these polythiols and the binding of the corresponding cavitands with therapeutic biomolecules
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-02457391
Contributor : Abes Star :  Contact
Submitted on : Tuesday, January 28, 2020 - 9:01:14 AM
Last modification on : Friday, October 23, 2020 - 4:52:14 PM
Long-term archiving on: : Wednesday, April 29, 2020 - 12:57:40 PM

File

TH2019OURRIBenjamin.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02457391, version 1

Citation

Benjamin Ourri. Architectures moléculaires complexes pour la reconnaissance de bio(macro)molécules d'intérêt thérapeutique. Other. Université de Lyon, 2020. English. ⟨NNT : 2020LYSE1001⟩. ⟨tel-02457391⟩

Share

Metrics

Record views

246

Files downloads

129