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Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01

Abstract : Graphical Abstract Highlights d bNAb LN01 neutralizes 92% of a 118-strain virus panel d LN01 targets the HIV-1 gp41 MPER, the TM region, and lipids d LN01-complexed MPER forms a continuous helix with TM d Most LN01 paratope residues interacting with MPER-TM and lipids are germline encoded
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https://hal.archives-ouvertes.fr/hal-02335126
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Submitted on : Wednesday, December 18, 2019 - 6:01:35 PM
Last modification on : Thursday, April 7, 2022 - 10:10:38 AM

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Dora Pinto, Craig Fenwick, Christophe Caillat, Chiara Silacci, Serafima Guseva, et al.. Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01. Cell Host and Microbe, Elsevier, 2019, 26 (5), pp.623-637.e8. ⟨10.1016/j.chom.2019.09.016⟩. ⟨hal-02335126⟩

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