Skip to Main content Skip to Navigation
Journal articles

Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway

Abstract : Mechanisms have evolved that allow cells to detect signals and generate an appropriate response. The accuracy of these responses relies on the ability of cells to discriminate between signal and noise. How cells filter noise in signaling pathways is not well understood. Here, we analyze noise suppression in the yeast pheromone signaling pathway and show that the poorly characterized protein Kel1 serves as a major noise suppressor and prevents cell death. At the molecular level, Kel1 prevents spontaneous activation of the pheromone response by inhibiting membrane recruitment of Ste5 and Far1. Only a hypophosphorylated form of Kel1 suppresses signaling, reduces noise, and prevents pheromone-associated cell death, and our data indicate that the MAPK Fus3 contributes to Kel1 phosphorylation. Taken together, Kel1 serves as a phospho-regulated suppressor of the pheromone pathway to reduce noise, inhibit spontaneous activation of the pathway, regulate mating efficiency, and prevent pheromone-associated cell death.
Document type :
Journal articles
Complete list of metadata

https://hal.sorbonne-universite.fr/hal-03531131
Contributor : Gestionnaire Hal-Su Connect in order to contact the contributor
Submitted on : Tuesday, January 18, 2022 - 9:52:07 AM
Last modification on : Friday, April 1, 2022 - 3:57:03 AM

File

mmc4.pdf
Publication funded by an institution

Identifiers

Citation

Ignacio Garcia, Sara Orellana-Muñoz, Lucía Ramos-Alonso, Aram Andersen, Christine Zimmermann, et al.. Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway. Cell Reports, Elsevier Inc, 2021, 37 (13), pp.110186. ⟨10.1016/j.celrep.2021.110186⟩. ⟨hal-03531131⟩

Share

Metrics

Record views

17

Files downloads

4