Harnessing the regulators to enhance viral vaccine efficacy
Résumé
CD4+CD25+FoxP3+ regulatory T cells (Tregs) are well known for their immune suppressive functions. While these tasks are important for maintaining immune tolerance and to prevent autoimmune and inflammatory diseases, suppression of innate and adaptive immune cells also leads to diminished immune response to vaccines including viral vaccines. Experimental models based on Treg depletion methods provided proof of concept that Tregs have negative impact on vaccine response. However such methodologies lack translational values due to adverse effects of Treg depletion. Therefore, targeting Tregs for vaccination purposes should aim at their transient inhibition of activities while keeping homeostatic functions intact.
Domaines
Médecine humaine et pathologie
Origine : Fichiers produits par l'(les) auteur(s)
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